The Beneficial Effects Of Stem Cell Therapy On Premature Ovarian Failure

In recent years, with the advancement of stem cell therapy, premature ovarian failure can be treated with stem cells to delay or even prevent the onset of ovarian aging. At SQ1 medical center, we have treated hundreds of patients. Some patients successfully restored menstruation and were able to pregnant after treatment, some patients also reported relieving body pain after treatment and became younger. We believe that stem cell therapy is the most promising approach for the treatment of premature ovarian failure.

Stem cell therapy for premature ovarian failure helps:

Relieve symptoms of irritability, insomnia, too many dreams, dryness, and sweating, and delay the onset of menopause syndromes
Partial compensation or restoration of ovarian function
Prevent follicular atresia, promote follicle renewal and enhance reproductive capacity
Repair the ovarian stroma tissue and prevent ovarian fibrosis, thus protecting the damaged ovary from the further lesion
Prevent germ cells from apoptosis and damage, and promote germ stem cell renewal
Replenish ovarian-like cells, increase estrogen secretion and balance its level.
Restoring ovulation, enabling natural conception, or laying a good basis for IVF
Improve fitness, stamina, and sensation level
Improve skin conditions by making it bright, smooth, firm, and hydrated, with the elimination of pigment deposition, and reduced wrinkles.

Indications Of Stem Cell Therapy For Premature Ovarian Failure

Irregular menstruation
Ovarian dysfunction
Vascular dysfunction
Loss of libido
Infertility
Gynecological inflammation
Menopausal depression
Osteoporosis
Wrinkled skin
Uterine fibroids
Ovarian tumor
Menopausal syndrome

Lots of pre-clinical and clinical research data show that mesenchymal stem cells from different sources have significant effects on the treatment of premature ovarian failure. Their effect is mainly through improving the microenvironment of ovarian tissue, immune regulation, inducing the development of follicles into granulosa cells, and promoting ovarian function and reproductive function restoration in patients with premature ovarian failure. Stem cell therapy has become a wise choice for patients with premature ovarian failure.

Learn More About Premature Ovarian Failure

The ovary, as the female internal reproductive organ, is regulated by the hypothalamus-pituitary-ovarian axis of the central nervous system. The ovary has the function of ovulation and hormone secretion to maintain the homeostasis of the female body. Premature ovarian failure (POF) refers to a disease status for women under age 40 and with regular menstruation, experiencing the onset of reproductive organ atrophy, persistent amenorrhea, increased gonadotropin levels, and decreased estrogen levels due to ovarian function decline.

In recent years, the incidence of premature ovarian failure is increasing and has been diagnosed more and more in the younger population. The major two threats of premature ovarian failure to the female reproductive system are the reduction of estrogen levels and the loss of fertility. Decreased estrogen levels rise the risk of osteoporosis and coronary heart diseases in women, while patients in childbearing years may have early amenorrhea, and loss of fertility, and those patients are also prone to psychological problems such as depression and anxiety.

Risk Factors For Premature Ovarian Failure

Many factors cause premature ovarian failure. In addition to the spontaneous aging of the ovary and environmental factors, there are many uncontrollable factors, such as genetic, psychological, autoimmune, iatrogenic, metabolic factors, FSH, and its receptor defects all could accelerate ovarian aging.

People with the following risk factors are more likely to develop premature ovarian failure:

People receiving radiation and chemotherapy for cancer
Patients who have received ovarian surgery, such as ovarian endometriosis, induced abortion, etc.
Patients who are accompanied by various genetic diseases that cause abnormal ovarian structure and function: such as Turner syndrome.
People with a bad lifestyle and adverse environmental factors: such as smoking, alcohol abuse, exposure to toxic and harmful substances, etc.
Patients possess certain autoimmune diseases: such as autoimmune thyroid disease
Long-term adverse mood, especially affected by negative emotions such as severe depression, chronic anxiety, anger, and fear
People who take emergency contraception
People who have a family history of premature ovarian failure

Clinical Symptoms Of Premature Ovarian Failure

Premature ovarian failure can lead to a decline in ovarian function, resulting in lower levels of sex hormones, and the onset of a series of symptoms:

Abnormal menstruation, with an irregular cycle, dark color, low menstrual flow, or even amenorrhea
Decreased sexual function and desire, vaginal dryness and relaxation, and discordant sexual life
Dry and aging of the skin, pigment deposit appearance or aggravation, dry and dull hair, hair loss
Subcutaneous fat accumulation, obesity
Decreased vaginal self-cleaning capacity, and prone to recurrent gynecological inflammation
Varying degrees of hot flashes, sweating, upset, insomnia, frequent mood swings
Osteoporosis, joint pain, became shortness, hunchback, or bone pain
Increased risk of cardiovascular disease and type 2 diabetes
Atrophic changes in the organs of the urogenital system

Advantages Of Stem Cell Treatment For Premature Ovarian Failure

The treatment methods for premature ovarian failure include medication, immunotherapy, and the most common combination of traditional Chinese and western medicine. However, these therapies can only help patients temporarily relieve the symptoms of premature ovarian failure to a certain extent, and even at the expense of over-drafting ovarian functions. That treatment cannot repair damaged ovarian tissue and structures and the side effects are extremely huge.

Compared with conventional therapy, stem cell therapy has incomparable advantages:

Stem cell therapy

Conventional treatment

Curative Treatment or diseases management

Stem cell therapy is a new therapy for the treatment of premature ovarian failure. Stem cells take effect through differentiation into ovarian tissue cells and vascular endothelial cells, thus repairing or regenerating damaged ovarian tissue, and restoring the ovarian structure. It is a therapy that can completely cure premature ovarian failure. If stem cell therapy is received at an early stage, it can reverse the damage to ovarian tissue, help patients improve symptoms from premature ovarian failure, and prevent the occurrence of other diseases.

Conventional therapy can only treat premature ovarian failure through disease management, mainly including medication, immunotherapy, and a combination of Chinese and Western therapy. That treatment only temporarily relieves the symptoms of premature ovarian failure by improving the ovarian environment, and cannot completely reverse the damage to ovarian function, and the effect of treatment varies from person to person.

Dosage

Once stem cells repaired damaged ovarian tissue, you can restore normal menstruation, gradually reduce the dosage of hormones needed, and even get rid of the dependence on those medications.

Stem cell experts based on your current level of disease and other comorbidities will design a customized protocol and decide, the number of stem cells, source of stem cells, and cycles of stem cell therapy.

If you choose medication treatment, usually you might be prescribed estrogen, progesterone, etc. But hormones are not meant to be used chronically, nor used too much at a single time, they need to be taken strictly according to the doctor's advice. Immunotherapy is only effective for premature ovarian failure due to antibody-related causes.

Side-effects

No Side-effects as stem cells are our cells that are used to treat the disease and regenerate ovarian tissue to regain proper functioning.

The side effects of hormone therapy for premature ovarian failure are very serious. Chronic use of hormones may cause stimulation to the breast and endometrium, resulting in breast hyperplasia, uterine fibroids, and excessive endometrial thickening. It is recommended to have regular breast and pelvic exams with ultrasound, take medicines as prescribed by the doctor, and not use hormones at your will.

The side effects of immunotherapy are also significant, which may cause disorders of the own immune system and cause more serious immune diseases.

Convenience

Stem cell therapy is performed by stem cell specialists which requires a special laboratory to process the stem cells and the medical set-up to extract and inject the stem cell.

The therapy is going to be injection-based and needs to be performed in a hospital.

It is relatively easy for patients with premature ovarian failure to use hormones, but they need to monitor their physical health all the time to prevent other side effects from causing damage to the body, and you might need to visit the hospital very often, which is very inconvenient.

Longevity

If treated in the early stage, the damaged ovarian tissue cells can be gradually regenerated, and the structure of the ovary can be restored with the recovery of ovarian function. normal menstruation can be restored. The treatment yield long-term beneficial effects.

Conventional disease management methods such as medication and immunotherapy can only relieve the symptoms related to premature ovarian failure, but do not help to treat ovarian damage caused by premature ovarian failure.

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How Can Stem Cell Therapy For Premature Ovarian Failure Work

Paracrine effect: stem cells can secrete a variety of cytokines (such as vascular endothelial growth factor, hepatocyte growth factor, insulin-like growth factor 1, etc.) to inhibit cell apoptosis and repair damaged tissues and cells.
Immune regulation: Stem cells inhibit the immune response and promote the repair of damaged tissues through immune regulation.
Anti-fibrosis: Stem cells can prevent ovarian fibrosis by repairing the ovarian stroma tissue, thus protecting the damaged ovary.
Multi-directional differentiation potential: After entering the damaged ovary, stem cells can directly reach the damaged site, and differentiate into some vascular endothelial cells and ovarian tissue cells to promote the repair of the damaged ovary.
Regulatory effect: stem cells can regulate ovarian function cells through change the expression of some genes in ovarian tissue

SQ1 Stem Cell Services

During the whole treatment process, we’ll provide complete and first-class medical services to you. And to ensure your treatment effect, you can consult your doctor any time after the treatment.