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Stem Cell Therapy
For Kidney Diseases

The high and growing incidence rate of kidney disease is becoming a public health issue. Stem cells therapy has been placed with great expectations in searching for innovative treatments for kidney disease. Currently, clinical trials have shown that stem cells are safe and effective in the treatment of various kidney diseases. Many patients have recovered kidney function with normal kidney function indicators and can live on as healthy people.

The Beneficial Effects Of Stem Cell Therapy On Kidney Diseases

The goal of stem cell therapy is to repair damaged kidney tissue and restore original kidney function, thus bringing new treatment options for kidney failure patients. In recent years, the development of regenerative medicine has made it possible to treat renal failure with stem cell therapy. For patients with severe lesions and frequent recurrences, stem cell therapy is undoubtedly a new and effective treatment method. It not only controls the progression of the disease but also may completely cure the disease, bringing great relief and improvement to the patients’ condition.

Stem cell therapy helps:

Reduction or elimination of protein amount of 24-hour urinary protein test
Relieve the symptoms of body weakness, poor appetite, and anemia
Delay the occurrence of acidosis and metabolic disorders
Improvement of uric acid, creatinine, and other disease indicators
Improvement of the renal imaging appearance
Reduction of the dialysis needs and shorten dialysis time
Improvement of renal function, reduce the pain from renal dialysis
Significantly improvement in survival rate and quality of life

Kidney Diseases That Stem Cell Therapy Can Treat or achieve long-term remission

Chronic kidney disease (CKD)
Chronic renal failure (CRF)
Diabetic Nephropathy (DN)
Lupus nephritis (LN)
Acute kidney injury (AKI)
Renal fibrosis
IgA nephropathy
Obstructive nephropathy
Glomerulus nephritis
Hypertensive nephropathy

At present, clinical trials and successful treatment cases around the world have confirmed that stem cell therapy is effective and safe in the intervention of various acute and chronic kidney diseases. The intervention and regulatory effect of stem cells can relieve renal fibrosis conditions, and improve renal function, thus providing a new clinical therapeutic option for patients with renal disorders.

Learn More About Kidney Diseases

The kidneys are important organs in the human body and consist of more than 1 million nephrons. Each nephron includes three parts, the glomerulus, the renal capsule, and the renal tubule. The glomerulus and the renal capsule make up the renal corpuscle. Its basic functions include: · Excretion of metabolites and harmful substances entering the human body · Maintain fluid balance through the production of urine · Maintain electrolyte and pH balance · Regulate blood pressure · Stimulate the red blood cells production · Promote the activation of vitamin D and calcium absorption

These functions of the kidneys ensure homeostasis in the human body and enable normal metabolism and maintains blood pressure levels within normal limits. Chronic kidney disease is an irreversible disease of kidney structure and function disorder caused by a variety of reasons. Due to the strong compensatory capacity of the kidneys, it is very easy to ignore the disease in the early stage, when there is only mild lesion and no obvious symptoms. So, chronic kidney disease is also called “The silent killer”. According to statistical data, as of 2022, 850 million people in the world suffer from kidney disease. Chronic kidney disease affects more than 10% of the world’s population, and the incidence is going up, causing 5 to 10 million deaths each year.

Risk Factors For Kidney Diseases

Many risk factors can lead to kidney disease. It is recommended that you perform a kidney function test if you have any of the following conditions:

Diabetes
Hypertension
Infection
Long-term medication history
Family history of kidney disease
Autoimmune disease/disorder
Long-term overeating
Long-term staying-up
Long-term and frequent urine hold
Long-term high-fat and high-salt diet

Clinical Symptoms Of Kidney Diseases

According to the internationally recognized guidelines specified by American Kidney Foundation, regarding the glomerular filtration rate (GFR), chronic kidney disease is divided into 5 stages in clinical settings.

Stage	Clinical Diagnosis	GFR
1	Kidney function is normal	filtration rate ≥90 mL/min (normal creatinine)
2	Compensation stage	filtration rate 60-89 mL/min (creatinine level about 133-176)
3	Decompensated stage	filtration rate 30-59 ml/min (creatinine level about 177-442)
4	Renal failure stage	filtration rate 15-29 ml/min (creatinine level about 443-707)
5	Uremic stage	filtration rate ≤ 15 ml/min (creatinine level about 707 or more)

Among those stages, stages 3-5 are considered renal failure, which is the result of the continuous progression of various chronic kidney diseases. Stage 5 is often referred to as “uremia”, which can be life-threatening if not treated in time. Patients with chronic kidney disease have different clinical symptoms in different stages:

Stage	Clinical Symptoms
1-3	Patients may have no symptoms, or only mild symptoms such as fatigue, loss of appetite, increased urination, and backache. A few patients have slightly more severe symptoms, such as nausea, vomiting, mild anemia, and edema.
4	As the disease progresses, kidney damage and other clinical symptoms will aggravate, and multi-system complications become prominent. Patients are usually presented with lethargy, muscle twitches and cramps, swelling of the lower limbs, skin itching and even gastrointestinal bleeding, chest pain, shortness of breath, hardship in lying down, and uncontrollable hypertension.
5	patients will show symptoms related to uremia, such as heart failure, gastrointestinal bleeding, mental disorders, muscle weakness, sensory nerve disorders, etc. The severe cases might even be life-threatening.

When you are experiencing those symptoms, the chronic kidney disease might already be at the doorstep, please go to a hospital for examination immediately!

Significant increase in urination during the night
Foamy urine that hard to vanish
Blood in urine
Increased blood pressure(hypertension)
Unexplainable loss of appetite, nausea, vomiting
Eyelid and lower extremity edema
Fatigue for an unknown reason

Advantages Of Stem Cell Treatment For Kidney Failure

The current treatment options for kidney disease mainly include medication, hormone therapy, hemodialysis, peritoneal dialysis, and kidney transplantation. None of these treatments can repair the damaged kidney tissue and restore the original kidney function, which is an important reason for the high mortality rate of chronic kidney disease.

Kidney transplantation possesses innate risks and complications such as immune rejection, at the same time, long-term use of anti-immune rejection drugs is required with a relatively high risk of infection. Compared with conventional therapy, stem cell therapy has unparalleled advantages:

Stem cell therapy

Conventional treatment

Curative Treatment or diseases management

Stem cell therapy is a new treatment for kidney disease that aims to differentiate stem cells into kidney cells to repair or regenerate kidney tissue and restore kidney function.

If stem cell therapy is applied at an early stage, kidney tissue damage can be reversed, at the same time, the treatment will reduce or eliminate drug dependence.

Including drug therapy, hormone therapy and dialysis therapy, which can only temporarily relieve symptoms, hemodialysis and peritoneal dialysis are incomplete alternative therapy and cannot reverse kidney injury.

Dosage

After stem cells repair kidney tissue, a patient would need less dosage of medication. If treatment is given at an early stage, the drug dependency can be completely reversed, and even remove the need to perform kidney dialysis or transplantation.

Patients who are taking medications will find the dosage of the medications continues to increase slowly and gradually thus developing drug resistance, later patients may also need hormone treatment or blood dialysis therapy.

Side-effects

There are no side effects since the stem cells come from the body itself, the immunogenicity is extremely low, and with a very strict quality control procedure, there are no side effects.

Anti-inflammatory drugs may have some side effects on the gastrointestinal tract and the whole body, for example, anorexia, nausea, vomiting, abdominal pain, obesity, colic, hypotension, muscle cramps, etc..

Convenience

Stem cell therapy is performed by stem cell experts and requires specialized laboratories to process stem cells. Corresponding medical equipment is also needed to extract and inject stem cells. Once the treatment is complete, there is no need for frequent or repeated treatment, patients can return to a high-quality life.

It’s relatively easy to take medications, but the patient needs to take them repeatedly every day, which is prone to the development of drug dependence.

Longevity

If treated in an early stage, in the long run, stem cell therapy can eliminate drug dependence, restore kidney function, and return the patient to a healthy life. If conducted at a later stage, stem cell therapy can still reduce drug dependence, and in rare cases, you might need several treatment regimens.

The effect of drug treatment is short-term, and it is necessary to take or apply anti-inflammatory drugs every day as prescribed. The effectiveness of the medication is usually a few hours or a day, and the patients need those medications for life.

End-stage

Stem cells are the fundamental part of our body, the main function of stem cells is to regenerate and repair damaged cells, produce new body cells thus repair and regenerate kidney tissue thus delaying or avoiding the necessity to conduct kidney transplantation surgery.

Kidney transplantation is the only treatment option for end-stage patients, but the high risk, limited donor, rejection reactions, and serious surgical complications are important concerning factors.

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How Can Stem Cell Therapy For Kidney Diseases Work

Clinically, stem cells utilized to treat kidney diseases mainly include mesenchymal stem cells and embryonic stem cells. When stem cells are infused into the body through veins, the stem cells will automatically identify the damaged part of the kidney and differentiate into glomerular cells and renal tubules cells, etc., thus rebuilding damaged kidney tissue and restoring kidney function.

The mechanism of stem cell therapy for kidney diseases is as follows:

Differentiation: Due to the homing effect, stem cells will automatically migrate to the kidney lesions and differentiate into innate renal cells, renal parenchymal cells, glomerular epithelial cells, etc. thereby repairing damaged kidneys, rebuilding renal blood circulation, and improving renal function.
Paracrine effect: stem cells can secret cytokines and nutrition factors to stimulate kidney cells to secrete erythropoietin, which can promote the production of red blood cells, which can relieve anemia in patients’ bodies.
Immune regulation effect: stem cells possess immune regulatory function, which can effectively relieve the symptoms of glomerulonephritis and thus improve kidney function.

SQ1 Stem Cell Services

During the whole treatment process, we’ll provide complete and first-class medical services to you. And to ensure your treatment effect, you can consult your doctor any time after the treatment.