Cardiomyocytes will be lost permanently after necrosis; The irreversible death of cardiomyocytes is one of the most important factors in the onset of heart diseases such as myocardial infarction and heart failure. Due to the limited regeneration capacity of cardiomyocytes, cardiovascular disease has become the “No.1 Killer” that threatens human health. The number of morbidity and mortality is increasing each year. Cardiovascular disease has become a major global public health issue.